diff --git a/science/rdkit/Makefile b/science/rdkit/Makefile
index ea8192ecc72a..2cde35d6bf91 100644
--- a/science/rdkit/Makefile
+++ b/science/rdkit/Makefile
@@ -17,6 +17,7 @@ LICENSE_FILE=	${WRKSRC}/license.txt
 
 BROKEN_FreeBSD_15_aarch64=	clang-17 crashes, see https://bugs.freebsd.org/bugzilla/show_bug.cgi?id=272652
 BROKEN_FreeBSD_15_amd64=	clang-17 crashes, see https://bugs.freebsd.org/bugzilla/show_bug.cgi?id=272652
+BROKEN_FreeBSD_15_i386=		clang-17 crashes, see https://bugs.freebsd.org/bugzilla/show_bug.cgi?id=272652
 
 BUILD_DEPENDS=	catch>0:devel/catch \
 		flex:textproc/flex \